the effect of eight weeks endurance training and high-fat diet on appetite-regulating hormones in rat plasma

objective(s):consumption of high-fat foods is one of the major causes of obesity. physical exercise is a strategy used to counteract obesity. the aim of this study was to investigate the effect of eight weeks endurance training and high-fat diet (hfd) on appetite-regulating hormones in rat plasma. materials and methods:twenty eight male wistar rats were randomly divided into four groups: control group with standard diet (csd), endurance training with a standard diet (esd), control group with high-fat diet (chfd) and endurance training with high-fat diet (ehfd). twenty-four hr after the last training session, the blood samples were obtained and analyzed for hormones levels. results: the significant increased weight gain and food intake and decreased plasma nesfatin-1 and pyy3-36 levels were observed in chfd group, while exercise under the hfd antagonized these effects. there were no significant changes in ghrelin, insulin and leptin levels in different groups. conclusion: these results suggest that exercise can prevent fattening effect of hfd. probably, performing exercise makes a reduction of food intake and weight gain in rat via the increase in nesfatin-1 and pyy levels. however, further studies are necessary to understand the exact mechanisms involved in this field.